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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)

Anti -Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila
Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
Catalog #D2728-01D
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 5-15ug/ml
ELISA: 1:3000-1:15000
Western Blot: 1:300-1:1500. Detects a band at ~74kD in pancreatic cell lysates.
Optimal dilutions to be determined by the researcher.
Positive Control human ovary
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to the internal region of human DLL4.
SpecificityRecognizes human Delta-like ligand 4 (DLL4). Species Sequence Homology: mouse, rat and chimpanzee.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDrosophila Delta Homolog 4


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