You are here:Home
»
Antibodies
»
Abs to Notch Proteins
»
Anti -Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)
Anti -Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila
Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity. | | | Catalog # | D2728-01D | | Applications | Suitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry (Paraffin): 5-15ug/ml | | ELISA: 1:3000-1:15000 | | Western Blot: 1:300-1:1500. Detects a band at ~74kD in pancreatic cell lysates. | | Optimal dilutions to be determined by the researcher. | | Positive Control | human ovary | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide corresponding to the internal region of human DLL4. | | Specificity | Recognizes human Delta-like ligand 4 (DLL4). Species Sequence Homology: mouse, rat and chimpanzee. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Drosophila Delta Homolog 4 |
External Links
|
