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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -DLL4 (Delta-like Protein 4, Drosophila Delta Homolog 4, Delta4, UNQ1895/PRO4341)

Anti -DLL4 (Delta-like Protein 4, Drosophila Delta Homolog 4, Delta4, UNQ1895/PRO4341)

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Specifications

Clone Host Grade Applications
Monoclonal Hamster Affinity Purified IH FC
The Notch signalling pathway is an evolutionarily conserved pathway in multi­cellular organisms, which is vital for cell­cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T­cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1(CD339), Jagged2, Delta like-1(DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM­family metalloproteases and gamma­secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL­NICD­Mastermind complex cascade (canonical pathway), or NF­kappaB­NICD and CSL­NICD­ Deltex complex signalling cascades (non­canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non­canonical pathway promotes differentiation.
Catalog #D2728-01K
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry and Functional assays. Other applications not tested.
Recommended DilutionsFlow Cytometry: 10ul labels 1x10e6 cells in 100ul
Immunohistochemistry: Frozen and paraffin sections
Optimal dilutions to be determined by the researcher.
HybridomaP3U1 myeloma cells with spleen cells from Armenian hamsters.
Recommended Positive ControlMouse spleen
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.    
Clone TypeMonoclonal
IsotypeIgG
Clone No12G28
HostHamster
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to mouse DLL4
SpecificityRecognizes mouse DLL4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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