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You are here:Home » Molecular Biology » MB-Hormones, Steroids » Deslorelin

Deslorelin

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Specifications

Deslorelin is a potent LHRH/GnRH agonist has a molecular formula of C64H83N17O12 Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt having a Mw of 1282.47. Deslorelin is being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It belongs to the family of drugs called gonadotropin-releasing hormone analogs. It is used for the induction of ovulation in mares. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.
Catalog #D3220-75
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight1282.47
Purity~98% (RP-HPLC, SDS-PAGE)
ConcentrationAs reported
FormSupplied as a lyophilized powder. No additives. Reconstitute in sterile dH2O to >100ug/ml, which can then be further diluted to other aqueous solutions. For long term storage add 0.1%HSA or BSA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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