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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Desmin (DES, CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate Filament Protein)

Anti -Desmin (DES, CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate
Filament Protein)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B IH
Desmin (DES), with 470-amino acid protein (about 52,000 Da), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Catalog #D3221-03B
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA.Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry: 1:1000-1:2000
ELISA: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No8A139
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
PurityPurified immunoglobulin
ImmunogenNi-NTA purified truncated recombinant Desmin expressed in E. coli strain BL21 (DE3)
SpecificityRecognizes truncated Desmin recombinant protein (WB), human Desmin recombinant protein (ELISA), human smooth muscle sarcoma (IHC).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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