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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Desmin (DES, CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate Filament Protein)

Anti -Desmin (DES, CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate
Filament Protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Desmin (53kD) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal and cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous.
Catalog #D3221-06
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
ApplicationsSuitable for use in Immunoblot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunoblot: 1:50-1:500
Immunohistochemistry (Frozen & paraffin sections): 1:10-1:100; ABC as detection reagent.
Optimum dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No4A45
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.065% sodium azide, before the addition of glycerol to 40%. No stabilizing proteins added.
PurityPurified by Protein G affinity chromatography.
ImmunogenDesmin isolated from human leiomyoma
SpecificityRecognizes Desmin. Reactive with human smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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