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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Desmoglein 1 (Desmoglein-1, Desmosomal Glycoprotein 1, DG1, DGI, DSG1, DSG, Cadherin Family Member 4, CDHF4, Pemphigus Foliaceus Antigen, PPKS1, SPPK1)

Anti -Desmoglein 1 (Desmoglein-1, Desmosomal Glycoprotein 1, DG1, DGI, DSG1, DSG, Cadherin
Family Member 4, CDHF4, Pemphigus Foliaceus Antigen, PPKS1, SPPK1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IF
Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
Catalog #D3221-82D
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:10
Western Blot: 1:10
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No27B2
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenDesmoglein 1
SpecificityRecognizes human desmoglein 1 at ~165kD. Does not cross react with desmoglein 2 or desmoglein 3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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