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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -DSG4 (Desmoglein 4, Cadherin family member 13, CDGF13, CDHF13, Desmoglein-4, LAH)

Anti -DSG4 (Desmoglein 4, Cadherin family member 13, CDGF13, CDHF13, Desmoglein-4, LAH)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified B
Desmoglein-4 is ~110kD type I transmembrane glycoprotein in the cadherin family of calcium-dependent cell adhesion molecules. Desmogleins interact with transmembrane Desmocollins to form the adhesive components of desmosomes on epithelial cells. Desmoglein-4 contains four cadherin repeats in its extracellular region and two desmoglein repeat domains in its cytoplasmic region. Alternate splicing generates an additional isoform with a substitution in the cytoplasmic region. Desmoglein-4 is expressed on keratinocytes and trichocytes in the epidermis and hair follicles. It is required for hair follicle development, and DSG4 mutations are associated with autosomal recessive hypotrichosis. Within aa24-631 (which includes the 26aa propeptide and the ECD), human Desmoglein-4 shares 82aa sequence identity with mouse and rat Desmoglein-4.
Catalog #D3221-85
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 200ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa24-631 from Desmoglein-4 expressed in NSO cells (Q86SJ6).
SpecificityRecognizes human Desmoglein-4. Species sequence homology: Recombinant human Desmoglein-1, Desmoglein-2, and Desmoglein-3 (1%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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