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You are here:Home » Antibodies » Abs to Neuroscience » Anti -DRP-2 (Dihydropyrimidinase Related Protein-2, CRMP-2, Collapsin Response Mediator Protein 2,N2A3, Unc-33-like Phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2)

Anti -DRP-2 (Dihydropyrimidinase Related Protein-2, CRMP-2, Collapsin Response Mediator
Protein 2,N2A3, Unc-33-like Phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients (5).
Catalog #D3575-55A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No10i33
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid.
PurityAscites
ImmunogenPurified recombinant DHP fusion protein.
SpecificityRecognizes human DRP-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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