You are here:Home
»
Antibodies
»
Abs to Neuroscience
»
Anti -DRP-2 (Dihydropyrimidinase Related Protein-2, CRMP-2, Collapsin Response Mediator Protein 2,N2A3, Unc-33-like Phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2)
Anti -DRP-2 (Dihydropyrimidinase Related Protein-2, CRMP-2, Collapsin Response Mediator
Protein 2,N2A3, Unc-33-like Phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B |
|
| DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3b inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3b (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3b activity in these patients (5). | | | Catalog # | D3575-55A | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:500-1:1,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b,k | | Clone No | 10i33 | | Host | Mouse | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid. | | Purity | Ascites | | Immunogen | Purified recombinant DHP fusion protein. | | Specificity | Recognizes human DRP-2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
