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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -DJ-1

Anti -DJ-1

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
DJ-1 belongs to the C56 peptidase family. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone and a sensor for oxidative stress. It apparently protects neurons against oxidative stress and cell death. Defects in PARK7 gene cause autosomal recessive early-onset Parkinson disease 7. Specifically, defects in PARK7 are characterized by PD onset before the age of 40, slow progression of the condition, and initial good response to levodopa. Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. However, cases of early-onset PD are sometimes found. PD generally arises as a sporadic condition but can be inherited as a simple Mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at an earlier age and are associated with atypical clinical features.
PD is characterized by bradykinesia, resting tremors, muscular rigidity, and postural instability, as well as by a significant clinical response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of protein aggregates) in surviving neurons at various areas of the brain.
Catalog #D3790-01E
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 0.05-0.2ug/ml
Western Blot: 0.5-1ug/ml
Immunohistochemistry: 5-10 ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder in PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide within carboxyl terminal of human DJ-1 protein (Swiss Prot: Q99497).
SpecificityRecognizes endogenous levels of human DJ-1 protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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