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You are here:Home » Antibodies » Abs to Dickkopf Proteins » Anti -Dkk2 (Dickkopf-related Protein 2, Dickkopf-2, Dkk-2, mDkk-2)

Anti -Dkk2 (Dickkopf-related Protein 2, Dickkopf-2, Dkk-2, mDkk-2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cysrich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk- 1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.
Catalog #D3795-03F
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa241 from mouse Dkk2.
SpecificityRecognizes mouse Dkk2 at ~57kD. A ~55kD and ~28kD Dkk2 fragments can also be detected in rat kidney tissue lysate. Species Crossreactivity: human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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