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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -Dnmt2 (tRNA (cytosine(38)-C(5))-methyltransferase, DNA (cytosine-5)-methyltransferase-like Protein 2, DNA Methyltransferase Homolog MmuIIP, DNA MTase Homolog MmuIIP, M.MmuIIP, Met-2, Trdmt1, Met2)

Anti -Dnmt2 (tRNA (cytosine(38)-C(5))-methyltransferase, DNA
(cytosine-5)-methyltransferase-like Protein 2, DNA Methyltransferase Homolog MmuIIP, DNA
MTase Homolog MmuIIP, M.MmuIIP, Met-2, Trdmt1, Met2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IF
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.
Catalog #D3931-62F
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptides corresponding to aa42 and aa364 from mouse Dnmt2.
SpecificityRecognizes mouse Dnmt2. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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