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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A) (Biotin)

Anti -Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA
MTase HsaIIIA, M.HsaIIIA, DNMT3A) (Biotin)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Catalog #D3931-70Q
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E170
HostMouse
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% sodium azide. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to mouse Dnmt3a.
SpecificityRecognizes mouse Dnmt3a. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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