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Anti -Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A)
Anti -Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA
MTase HsaIIIA, M.HsaIIIA, DNMT3A)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. This nuclear protein localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development. DNA methylation is coordinated with methylation of histones. Dnmt3a associates with HDAC1 through its ADD-type zinc-finger. It binds to the ZNF238 transcriptional repressor and is also known to interact with other DNA methyltransferases like Dnmt1 and Dnmt3b. | | | Catalog # | D3931-70V | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Western Blot: 0.5-2ug/ml, observed in human and rat liver lysates on ~100KD bands | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-DKNATKAGDDEPEY, from SNMT3A, at the internal region of the protein (NP_072046.2, NP_715640.2, NP_783329.1). | | Specificity | Recognizes human DNMT3A. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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