Anti -DNA Methyltransferase 3B (DNA (Cytosine-5)-methyltransferase 3 beta, Dnmt 3B,
Dnmt3b, Cytosine 5-methyltransferase 3B, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB,
ICF, M.HsaIIIB, MGC124407, RP23-89H14.3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IC |
|
| DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) is a DNA methyltransferase that is essential for mammalian development potentially through its transcription and repression activity (1).It is one of three different families of DNA (cytosine-5) methyltransferases, Dnmt1, Dnmt2, | | | Dnmt3 (Dnmt3a and Dnmt3b).Dnmt3a and Dnmt3b form complexes with the major maintenance enzyme Dnmt1 (2). Depletion of Dnmt3b has been shown to induce apoptosis of | | | human cancer cells, and reactivate methylation-silenced gene expression (3).Methylation defects in ICF syndrome may also result from impaired stimulation of Dnmt3b activity (4). | | | | | | Applications: | | | Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. | | | Catalog # | D3931-73K | | Recommended Dilution | Western Blot: 1:1000-1:5000 | | Immunocytochemistry: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H343 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues in human Dnmt3b. | | Specificity | Recognizes human Dnmt3b. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=2.1.1.37 |
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