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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -DNA Methyltransferase 3B (DNA (Cytosine-5)-methyltransferase 3 beta, Dnmt 3B, Dnmt3b, Cytosine 5-methyltransferase 3B, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB, ICF, M.HsaIIIB, MGC124407, RP23-89H14.3)

Anti -DNA Methyltransferase 3B (DNA (Cytosine-5)-methyltransferase 3 beta, Dnmt 3B,
Dnmt3b, Cytosine 5-methyltransferase 3B, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB,
ICF, M.HsaIIIB, MGC124407, RP23-89H14.3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IC
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) is a DNA methyltransferase that is essential for mammalian development potentially through its transcription and repression activity (1).It is one of three different families of DNA (cytosine-5) methyltransferases, Dnmt1, Dnmt2,
Dnmt3 (Dnmt3a and Dnmt3b).Dnmt3a and Dnmt3b form complexes with the major maintenance enzyme Dnmt1 (2). Depletion of Dnmt3b has been shown to induce apoptosis of
human cancer cells, and reactivate methylation-silenced gene expression (3).Methylation defects in ICF syndrome may also result from impaired stimulation of Dnmt3b activity (4).
Applications:
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Catalog #D3931-73K
Recommended DilutionWestern Blot: 1:1000-1:5000
Immunocytochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H343
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues in human Dnmt3b.
SpecificityRecognizes human Dnmt3b. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.1.1.37


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