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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -DNA Methyltransferase 3L (Dnmt 3L, DNA Cytosine 5 Methyltransferase 3 Like Protein)

Anti -DNA Methyltransferase 3L (Dnmt 3L, DNA Cytosine 5 Methyltransferase 3 Like Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IP
DNMT 3L is a nuclear protein which has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.
Catalog #D3931-76A
Cellular Localization Nuclear.
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.6mg/ml
Form0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: C-GLLQRRRKWRSQL conjugated to KLH, corresponding to amino acids 152-164 of Human DNMT 3L.
SpecificitySpecies Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (76% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDNA Methyltransferase 3 Like Protein


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