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You are here:Home » Antibodies » Abs to Enzymes, Polymerase » Anti -DNA polymerase delta interaction protein, p46 (POLDIP3, SKAR, polymerase (DNA-directed), delta interacting protein 3, 46kD DNA polymerase delta interaction protein, KIAA1649, p46, PDIP46, Polymerase delta-interacting protein 3)

Anti -DNA polymerase delta interaction protein, p46 (POLDIP3, SKAR, polymerase
(DNA-directed), delta interacting protein 3, 46kD DNA polymerase delta interaction
protein, KIAA1649, p46, PDIP46, Polymerase delta-interacting protein 3)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
The mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) signaling pathways promote cell growth and cell cycle progression in response to nutritional, energy, and mitogenic cues. In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstream of mTOR and PI3K, suggesting that translational control through the phosphorylation of S6 regulates cell growth. SKAR is a specific binding partner and substrate of S6K1 but not S6K2. Serines 383 and 385 of human SKAR are insulin-stimulated and rapamycin-sensitive S6K1 phosphorylation sites. SKAR is nuclear protein with homology to the Aly/REF family of RNA binding proteins, which has been proposed to couple transcription with pre-mRNA splicing and mRNA export.
Catalog #D3935-23D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySerum
ImmunogenSynthetic linear peptide corresponding to SKAR (KLH).
SpecificityRecognizes human SKAR. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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