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You are here:Home » Antibodies » Abs to Notch Proteins » Anti -DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF Repeat Containing Transmembrane Protein, BET)

Anti -DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF
Repeat Containing Transmembrane Protein, BET)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
DNER, a neuron-specific EGF-like repeat-containing transmembrane protein, acts as a functional ligand of Notch and regulates morphologic differentiation of glia in the vertebrate brain. Like other Notch ligands, DNER specifically binds to Notch1-expressing cells and induces intracellular cleavage of Notch1 at the S3 site, thus mediating the Notch signaling pathway. The protein exerts a regulatory role in dendritic patterning of the central nervous system neurons. Human DNER gene is localized on chromosome 2q36.3. The protein is strongly expressed in several types of postmitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells.
Catalog #D4016-85C
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa170-190 (QATVTLPTWQPKTGQKVVEMK) of human DNER.
SpecificityRecognizes human DNER. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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