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You are here:Home » Antibodies » Abs to Disease Markers » Anti -DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

Anti -DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The 'Disrupted In Schizophrenia' gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.
Catalog #D8066-83B
Cellular Localization DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm. It co-localizes with the following organelle structure antibodies: PD1, calnexin, GIANTIN, 58K, Rab4, LAMP-1, RAP1, KDEL, and catalase.
Positive Control Mouse brain sections (neurons and glia)
ApplicationsSuitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceMouse
Concentration~0.95mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
PurityPurified by peptide immunoaffinity chromatography.
ImmunogenA synthetic peptide made to an internal region (within residues 700-800) of the mouse DISC1 protein. [Swiss-Prot# Q811T9]. Homology: 100% with mouse and rat proteins and 42% with human protein.
SpecificityReacts with the murine DISC1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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