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Anti -DISC1, CT (Disrupted In Schizophrenia 1, KIAA0457)
Anti -DISC1, CT (Disrupted In Schizophrenia 1, KIAA0457)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| Disrupted in Schizophrenia 1 (DISC1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. DISC1 has been shown to interact with multiple proteins of the centrosome and cytoskeletal system including MIPT3, MAP1A and NUDEL; proteins that localize receptor to membranes, including ACTN2 and beta-4-spectrin; and proteins that transducer signals from membrane receptors. This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. | | | Catalog # | D8066-83H | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Immunohistochemistry (Formalin-fixed, paraffin-embedded): 10-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-terminal residues of human DISC1 (KLH). | | Specificity | Recognizes human DISC1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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