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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Dog1

Anti -Dog1

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant IH
Dog1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the Dog1 antibody identified 11% more cases than c-Kit antibody . Dog1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, Dog1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.
Catalog #D8079-35
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:50. Formalin/paraffin for 20 min at RT. Staining of formalin fixed sections require heat induced antigen retrieval using EDTA, pH 8, heating to 98°C for 20 min
Optimal dilutions to be determined by the researcher.
Positive Control Gastrointestinal stromal tumors
Cellular Localization Cytoplasmic & Membranous
Molecular Weight 78kD
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No10A20
HostRabbit
SourceHuman
FormTissue culture supernatant with 15mM sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide of human Dog1
SpecificityRecognizes human Dog1
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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