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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -Dok1 (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860, p62(dok), p62dok, P62DOK, pp62)

Anti -Dok1 (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860,
p62(dok), p62dok, P62DOK, pp62)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Catalog #D8080-01P
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot:1:500-1:1,000
Immunohistochemistry:1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human p62Dok around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).
SpecificityRecognizes human p62Dok. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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