Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Binding Proteins » Anti -Dok1 (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860, p62(dok), P62DOK, pp62)

Anti -Dok1 (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860,
p62(dok), P62DOK, pp62)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
p62Dok was first identified as a 62 kD RasGAP-binding protein in v-Abl transformed B cells and in Bcr-Abl expressing cells. It is a novel protein with features of a signaling molecule. Association of p62Dok with GAP correlates with its tyrosine phosphorylation. It is rapidly tyrosine-phosphorylated upon activation of the c-Kit receptor, implicating it as a component of a signal transduction pathway downstream of receptor tyrosine kinases. The protein contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Thefunctional role of the protein is implicated in the regulation of a wide range of physiological responses, including negative regulation of cytokines, enhanced cell migration, filopodia extension and tumor suppression. The adapter protein also plays distinct roles in mediating platelet activation in hemostasis. human p62Dok gene maps on chromosome 2 at 2p13.
Catalog #D8080-01U
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochestry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human p62Dok around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).
SpecificityRecognizes human p62Dok. Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDocking Protein 1, 62kDa (Downstream of Tyrosine Kinase 1)


External Links