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You are here:Home » Antibodies » Antibodies-Binding Proteins » Anti -Dok3 (Docking Protein 3, DOK Like Protein, DOKL, FLJ22570)

Anti -Dok3 (Docking Protein 3, DOK Like Protein, DOKL, FLJ22570)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Downstream of kinase 3 (DOK3) is a 53kD (predicted) member of the DOK family of cytoplasmic adaptor proteins and is expressed in B cells and macrophages. It contains one pleckstrin homology region (aa63-179) and an IRS-type phosphotyrosine binding domain (PTB) (aa213-317). Alternate splicing generates additional isoforms with extensive N-terminal and C-terminal truncations and substitutions. Phosphorylation of tyrosine residues in DOK3 regulates its interaction with SH2 and SH3 containing proteins, leading to inhibition of signaling from immunoreceptors. Over (aa181-271), human DOK3 shares approximately 80% aa sequence identity with mouse and rat DOK3.
Catalog #D8080-06C
ApplicationsSuitable for use Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.25ug/ml
Optimal dilutions to be determined by the researcher.
HybridomaMyeloma cells with spleen cells from Balb/c mice.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No11D44
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS with 5% trehalose Reconstitute with sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to aa181-271 from DOK3 expressed in E. coli (Q7L591).
SpecificityRecognizes human DOK3. Species Cross reactivity: Detects endogenous human DOK3 at~65kD in Western blots.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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