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Anti -DOK6 (Docking Protein 6, Downstream of Tyrosine Kinase 6, DOK5L, DOK-6)
Anti -DOK6 (Docking Protein 6, Downstream of Tyrosine Kinase 6, DOK5L, DOK-6)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C-terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. | | | Catalog # | D8080-14C | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum. | | Immunogen | Synthetic peptide corresponding to aa121-136 of human DOK-6. | | Specificity | Recognizes human DOK-6. Species sequence homology: chicken. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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