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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Dopamine Beta Hydroxylase, CT (DBH, Dopamine beta Monooxygenase)

Anti -Dopamine Beta Hydroxylase, CT (DBH, Dopamine beta Monooxygenase)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Purified B IH
The production of neurotransmitters is controlled by environmental stimuli, which send signals through second messengers and protein kinase pathways. Regulation of gene expression of dopamine beta hydroxylase and tyrosine hydroxylase, two of the catecholamine biosynthetic enzymes, by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis. Dopamine beta-hydroxylase catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system. The disruption of the DBH gene is thought to cause changes in development and behavior in certain models. Both DBH and the multiple regulatory pathways of DBH are of increasing research in many neurological diseases.
Catalog #D9010-02
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000; Recognizes single (or double) MW ~70-75000 band(s) in SDS-solubilized, DTT-reduced human adrenal medulla subjected to SDS-PAGE
Immunohistochemistry: Evaluated in the locus coeruleus of formaldehyde-fixed, cryopreserved human and monkey brain.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified
ImmunogenPeptide corresponding to the C-terminal region of human Dopamine Beta Hydroxylase. Cellular Localization: exists in soluble form (in chromaffin granules) and as membrane-bound.
SpecificityRecognizes human Dopamine Beta Hydroxylase, CT. Species Crossreactivity: monkey, mouse. Does not recognize sheep, canine or rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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