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You are here:Home » Antibodies » Abs to Enzymes, Decarboxylase » Anti -Dopamine Decarboxylase (DOPA)

Anti -Dopamine Decarboxylase (DOPA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Dopa decarboxylase (DDC), also known as AADC, is a homodimeric vitamin B 6-dependent enzyme that catalyzes the decarboxylation of hydroxylated aromatic amino acids (Accession # P20711). DDC is expressed in the adrenal medulla and catecholaminergic neurons. It catalyzes the final step in the synthesis of the neurotransmitters dopamine and serotonin. Defects in DDC are associated with the development of schizophrenia, Parkinson's disease, and hypertension. Human DDC shares 89% aa sequence identity with mouse and rat DDC.
Catalog #D9013-01F
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml. Detects human DDC in cell or tissue extracts
Direct ELISA: 0.5-1ug/ml; The detection limit is ~2ng/well.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG2b
Clone No7H245
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenSf21-derived recombinant human DDC (aa1-480) Accession # P20711
SpecificityRecognizes human DDC. Species Sequence Homology: mouse and rat, 89%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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