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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » Doramapimod, Free Base (1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea) (BIRB 796, DB03044, D03736)

Doramapimod, Free Base
(1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1
-yl]urea) (BIRB 796, DB03044, D03736)

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Specifications

Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
Catalog #D9023
SolubilitySoluble in DMSO at 50mg/ml. Soluble in ethanol at 33mg/ml. Very poorly soluble in water. Maximum solubility in plain water is estimated to be about 5-20uM.
Melting Point114-142ºC
Elemental AnaylsisC = 70.56%
H = 7.07%
N = 13.27%
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number285983-48-4
Molecular FormulaC31H37N5O3
Molecular Weight527.66
Purity~90%
FormSupplied as a white to off-white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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