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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -DORFIN (E3 Ubiquitin-protein Ligase RNF19A, Double Ring-finger Protein, RING Finger Protein 19A, p38, RNF19A, RNF19)

Anti -DORFIN (E3 Ubiquitin-protein Ligase RNF19A, Double Ring-finger Protein, RING Finger
Protein 19A, p38, RNF19A, RNF19)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
Dorfin is an E3 ubiquitin ligase which mediates ubiquitination of cellular proteins. Dorfin contains two RING-finger motifs and an IBR (in between RING fingers) motif. Dorfin interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. Dorfin is of interest in Parkinson's Disease, as it binds and ubiquitylates synphilin 1 (SNCAIP-interacts with alpha synuclein) in neurons. Furthermore, Dorfin expression is increased in Lewy bodies, the characteristic neuronal inclusions in Parkinson's diseased brains. In normal subjects, Dorfin is widely expressed at low levels with higher levels found in the heart and is ubiquitously expressed in the central nervous system. Alternatively spliced transcript variants encoding the same protein have been reported.
Catalog #D9027-01B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-QTMELKVAIQTEI, from DORFIN, at C-terminal (NP_056250.3, NP_904355.1).
SpecificityRecognizes DORFIN. Species sequence homology: Bovine, canine, human and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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