USBio Logo

D9060 Dovitinib, Free Base (4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone) (CHIR-258, TKI-258) CAS: 405169-16-6

Specifications
References
CAS Number
405169-16-6
Grade
Highly Purified
Molecular Formula
C21H21FN6O
Molecular Weight
392.43
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Dovitinib is a small-molecule multi-targeted receptor tyrosine kinase inhibitor. Dovitinib inhibited Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150nM and 90nM, respectively. The phosphorylation of each fusion gene, ERK, and STAT5 was inhibited as well at the same time. Dovitinib treatment also inhibited proliferation and survival of the FGFR1OP2-FGFR1-positive KG1 and KG1A cell lines and resulted in cell apoptosis. Furthermore, Dovitinib significantly inhibited the survival of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently.

Solubility
Soluble in DMSO
Melting Point
280-312ºC
Elemental Analysis
Calculated C: 64.27% H: 5.39% F: 4.84% N: 21.42%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Form
Supplied as a yellow to green crystalline powder
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Chase, A., et al. Blood 110: 3729-3734 (2007). 2. Trudel, S., et al., Blood 105: 2941-2948 (2005). 3. Lee, S.H., et al., Clin. Cancer Res. 11: 3633-3641 (2005). 4. Lopes de Menezes, D.E., et al., Clin. Cancer Res. 11: 5281-5291 (2005). 5. Xin, X., et al., Clin. Cancer Res. 12: 4908-4915 (2006).
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved