Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil,
Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)
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| Doxorubicin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin has also been reported to exhibit anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis. | | | Catalog # | D9099-43 | | Apperance | Orange red solid | | Solubility | Soluble in DMSO, dichloromethane and ethyl acetate. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Light Sensitive. | | CAS Number | 23214-92-8 | | Molecular Formula | C27H29NO11 | | Molecular Weight | 543.5 | | Source | Streptomyces peucetius MST-AS5775 | | Purity | ~99% | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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