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You are here:Home » Biochemicals » Biochem-Antibiotics » Doxycycline Monohydrate (Vibramycin)

Doxycycline Monohydrate (Vibramycin)


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Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.
Catalog #D9100
Doxycycline monohyrate is very soluble in fats and oils. It is transported in serum bound to serum lipids and fat globules. It is taken up in oils. It is transported in serum bound to serum lipids and fat globules. It is taken up into tissues by crossing the bilipid cellular membrane. The monohydrate is the base molecule hydrated with one molecule of water. Doxycycline will not degrade into an epianhydro form.
AppearanceLight yellow powder
Conforms to reference
pH: 5.0-6.5
Water: 3.6-4.6%
Related substances: Conforms to reference
Solubility Doxycycline monohydrate is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.
CAS Number17086-28-1
Molecular FormulaC22H24N2O8H2O
Molecular Weight462.46
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesa-6-deoxy-5-hydroxytetracycline monohydrate

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