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You are here:Home » Antibodies » Abs to Autophagy » Anti -DRAM, NT (Damage-Regulated Autophagy Modulator)

Anti -DRAM, NT (Damage-Regulated Autophagy Modulator)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy (1), a process that degrades cytosolic proteins and organelles (reviewed in 2). It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers (3) highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Catalog #D9370-02
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml. See D9370-02A for control peptide.
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
Immunogen16 amino acid peptide from near the amino terminus of human DRAM (GenBank accession no. AAH18435)
SpecificityRecognizes human DRAM. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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