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You are here:Home » Antibodies » Abs to Autophagy » Anti -DRAM1 (DNA Damage-regulated Autophagy Modulator Protein 1, Damage-regulated Autophagy Modulator, DRAM)

Anti -DRAM1 (DNA Damage-regulated Autophagy Modulator Protein 1, Damage-regulated
Autophagy Modulator, DRAM)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
DRAM is an important lysosomal membrane protein of the p53 tumor suppressor pathway. It is required for the induction of macroautophagy and as an effector of p53-mediated death. DRAM expression is induced due to cellular stress via endogenous p53 leading to bulk degradation of cytoplasmic components. It is necessary but not sufficient for apoptotic cell death from p53, while over expression of DRAM alone causes minimal cell death. Quantitative PCR revealed that DRAM was significantly down regulated in tumor cell lines by methylation-dependent transcriptional silencing, particularly in cancers lacking other mechanisms of p53 inactivation.
Catalog #D9370-02B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptide corresponding to aa50-100 of human DRAM.
SpecificityRecognizes human DRAM. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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