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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -DRIP-130 (Vitamin D Receptor Interacting Protein 130, Sur2, CRSP130, ARC130, NAT140, TRAP150b)

Anti -DRIP-130 (Vitamin D Receptor Interacting Protein 130, Sur2, CRSP130, ARC130, NAT140,


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Clone Host Grade Applications
Polyclonal Rabbit Purified E B IP
DRIPs are a distinct set of ligand-dependent proteins that interact with the vitamin D receptor (VDR). Together, these proteins constitute a new cofactor complex. DRIPs bind to several nuclear receptors to mediate ligand-dependent enhancement of transcription by VDR and the thyroid-hormone receptor in cell-free transcription assays. The DRIPs are almost indistinguishable from components of another cofactor complex called ARC, which is recruited by other types of transcription activators to mediate transactivation on chromatin-assembled templates. The role of nuclear-receptor ligands may, in part, be to recruit such a cofactor complex to the receptor and, in doing so, to enhance transcription of target genes. In humans, interaction with Sur-2 is required for transcription to be activated by the activation domain of a transcription factor of the ETS-family in response to activated mitogen-activated protein (MAP) kinase.
Catalog #D9475
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. Detects a 130kD band
Immunoprecipitation: 1:100-1:200. Pre-clearing of the lysate with a non-specific rabbit IgG is helpful to reduce background.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins added.
PurityPurified serum
ImmunogenSynthetic peptide corresponding to mouse DRIP-130 residues 897-916 (based on human DRIP-130 residue numbering) conjugated to KLH.
SpecificityRecognizes mouse DRIP-130 (vitamin-D-receptor interacting protein 130). Used to detect DRIP130 using nuclear extracts from mouse thymus, spleen and brain. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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