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Anti -DSCAM (Down Syndrome Cell Adhesion Molecule)
Anti -DSCAM (Down Syndrome Cell Adhesion Molecule)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IC |
|
| DSCAM (Down syndrome cell adhesion molecule) is a 230 kD axonal guidance molecule that is a member of the Ig superfamily. It is synthesized as a mature, 2005 amino acid (aa) type I transmembrane glycoprotein. There is a large, 1578 aa extracellular domain (ECD) and a 389 aa cytoplasmic region. The ECD shows ten C2-type Ig-like domains and six fibronectin type III repeats. One soluble splice form is known which contains all the ECD modules and ends after aa # 1571 of the precursor. This form has a unique C-terminal ten amino acids. DSCAM is found on axonal and dendritic processes. It also forms homophilic complexes among cells. | | | Overexpression is associated with Down’s syndrome. The ECD of human is 98% and 77% aa identical to mouse and zebrafish DSCAM ECD, respectively. | | | Catalog # | D9635-51 | | Applications | Suitable for use in Immunocytochemistry, ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Immunocytochemistry: 10ug/ml | | ELISA: 0.5-1ug/ml | | Western Blot: 1-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 7H210 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile ddH2O or sterile 40-50% glycerol. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | NS0-derived recombinant human DSCAM (aa18-1595) Accession # O60469 | | Specificity | Recognizes human DSCAM. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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