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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -DSCAM (Down Syndrome Cell Adhesion Molecule)

Anti -DSCAM (Down Syndrome Cell Adhesion Molecule)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC
DSCAM (Down syndrome cell adhesion molecule) is a 230 kD axonal guidance molecule that is a member of the Ig superfamily. It is synthesized as a mature, 2005 amino acid (aa) type I transmembrane glycoprotein. There is a large, 1578 aa extracellular domain (ECD) and a 389 aa cytoplasmic region. The ECD shows ten C2-type Ig-like domains and six fibronectin type III repeats. One soluble splice form is known which contains all the ECD modules and ends after aa # 1571 of the precursor. This form has a unique C-terminal ten amino acids. DSCAM is found on axonal and dendritic processes. It also forms homophilic complexes among cells.
Overexpression is associated with Down’s syndrome. The ECD of human is 98% and 77% aa identical to mouse and zebrafish DSCAM ECD, respectively.
Catalog #D9635-51
ApplicationsSuitable for use in Immunocytochemistry and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry: 8-25ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to remoing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
Clone No7H210
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a powder lyophilized from a solution containing PBS with trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived recombinant human DSCAM long isoform (aa18-1595), Accession # O60469
SpecificityRecognizes human DSCAM.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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