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D9831-01B Goat Anti-CYBRD1 (Cytochrome B Reductase 1, Duodenal Cytochrome B, Ferric-chelate Reductase 3, DCYTB, FRRS3)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC
Crossreactivity
Hu Mo
Accession #
NP_079119.3
Gene ID
79901
Shipping Temp
Blue Ice
Storage Temp
-20°C

Ferric-chelate reductase that reduces Fe3+ to Fe2+. Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe3+ thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.

Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
ELISA (Peptide): 1:16,000 Western Blot: 0.1ug/ml using human colon lystates showed bands at 35kD, 26kD and 28kD. Immunohistochemistry (Paraffin): 2-5ug/ml using human testis shows membranous staining in primarily myofibroblasts of the basement membrane surrrounding the seminiferous tubules. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to CRNLALDEAGQRSTM at the C-terminal, from human CYBRD1 (NP_079119.3). Species Sequence Homology: bovine, canine and porcine
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CYBRD1. Species Crossreactivity: mouse
References
1. Atanasova BD, Li AC, Bjarnason I, Tzatchev KN, Simpson RJ. Duodenal ascorbate and ferric reductase in human iron deficiency. Am J Clin Nutr. 2005 Jan;81(1):130-3.
USBio References
No references available
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