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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -DUSP11 (Dual Specificity Phosphatase 11, RNA/RNP Complex-interacting Phosphatase)

Anti -DUSP11 (Dual Specificity Phosphatase 11, RNA/RNP Complex-interacting Phosphatase)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified B IH IC
DUSP11 is a member of the dual specificity protein phosphatase subfamily. These phosphatasses inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibillity of their expression by extracellular stimuli. This protein is localized to the nucleus, and is novel in that it binds directly to RNA and splicing factors, and thus suggested to participate in nuclear mRNA metabolism.
Catalog #D9840-42
ApplicationsSuitable for use in ELISA, Immunohistochemistry, Immunocytochemistry and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:200
Immunocytochemistry: 1:200
Western Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa264-330 of human DUSP11
Protein GI Number4503415
Protein Accession NumberNP_003575.1
SpecificityRecognizes human DUSP11.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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