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You are here:Home » Molecular Biology » MB-Enzymes, Phosphatase » DUSP14, Recombinant, Human (Dual Specificity Protein Phosphatase 14, Mitogen-activated Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein Tyrosine Phosphatase, MKP-L)

DUSP14, Recombinant, Human (Dual Specificity Protein Phosphatase 14, Mitogen-activated
Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein
Tyrosine Phosphatase, MKP-L)

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Specifications

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.
Catalog #D9840-48
Species Homo sapiens
Source E. coli
Primary Sequence (aa) 198
Domain (aa) Full-length
Tag/Fusion Partner T7 Tag
Applications Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested.
Quality Control SDS-PAGE Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
Important note This recombinant enzyme has NOT been tested with regard to biological activity.
SourceE. coli
PurityHighly purified
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative added.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDual Specificity Phosphatase 14, EC=3.1.3.16, EC=3.1.3.48


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