DUSP14, Recombinant, Human (Dual Specificity Protein Phosphatase 14, Mitogen-activated
Protein Kinase Phosphatase 6, MAP Kinase Phosphatase 6, MKP6, MKP-6, MKP-1-like Protein
Tyrosine Phosphatase, MKP-L)
Pricing
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| In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling. | | | Catalog # | D9840-48 | | Species | Homo sapiens | | Source | E. coli | | Primary Sequence (aa) | 198 | | Domain (aa) | Full-length | | Tag/Fusion Partner | T7 Tag | | Applications | Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested. | | Quality Control | SDS-PAGE Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. | | Important note | This recombinant enzyme has NOT been tested with regard to biological activity. | | Source | E. coli | | Purity | Highly purified | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Dual Specificity Phosphatase 14, EC=3.1.3.16, EC=3.1.3.48 |
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