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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Dynorphin A

Anti -Dynorphin A

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Cells are found in the paraventricular and supraoptic nucleus and fibers are found in the lateral hypothalamus in rat brain of 4% FA perfused colchicine tissue.
Catalog #D9902-03
ApplicationsSuitable for use in RID and Immunohistochemistry. Other applications not tested.
Recommended DilutionRID: 1:10,000
Immunohistochemistry (Paraffin): Requires antigen retrieval using heat treatment prior to staining. Sodium citrate buffer, pH 6.0, is recommended. Overnight incubation recommended.
Immunohistochemistry (Frozen): 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourcePorcine
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.1% BSA, 0.09% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa209-225, YGGFLRRIRPKLKWDNQ of porcine Dynorphin A.
Cellular LocalizationSecreted. Species Sequence Homology (100%): mouse, bovine, guinea pig.
SpecificityRecognizes porcine Dynorphin A. Blocks dynorphin 1-17 and 1-8 but not with other related peptides.
Species CrossreactivityHuman, rat, rhesus monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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