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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum IH

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Cells are found in the paraventricular and supraoptic nucleus and fibers are found in the lateral hypothalamus in rat brain of 4% FA perfused colchicine tissue.
Catalog #	D9902-03
Applications	Suitable for use in RID and Immunohistochemistry. Other applications not tested.
Recommended Dilution	RID: 1:10,000
	Immunohistochemistry (Paraffin): Requires antigen retrieval using heat treatment prior to staining. Sodium citrate buffer, pH 6.0, is recommended. Overnight incubation recommended.
	Immunohistochemistry (Frozen): 1:100-1:500
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Porcine
Concentration	Not determined
Form	Supplied as a liquid in PBS, 0.1% BSA, 0.09% sodium azide.
Purity	Serum
Immunogen	Synthetic peptide corresponding to aa209-225, YGGFLRRIRPKLKWDNQ of porcine Dynorphin A.
Cellular Localization	Secreted. Species Sequence Homology (100%): mouse, bovine, guinea pig.
Specificity	Recognizes porcine Dynorphin A. Blocks dynorphin 1-17 and 1-8 but not with other related peptides.
Species Crossreactivity	Human, rat, rhesus monkey.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.