Anti -Ezrin (EZR, CVIL, CVL, Cytovillin, DKFZp762H157, FLJ26216, MGC1584, p81, VIL2,
Villin-2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| Human ezrin, otherwise known as villin 2, an 80kD cytoplasmic peripheral membrane protein and member of the ezrin, radixin, moesin (ERM) protein family, which acts as protein-tyrosine | | | kinase substrate. Ezrin is enriched in microvilli and other cell surface structures and plays a key role in cell surface structure adhesion, membrane trafficking, motility and organization Ezrin acts as a linker protein between the plasma membrane and the actin cytoskeleton, and provides anchorage for cell surface molecules such as ICAM and CD44. Studies have implicated ezrin in the metastatic capacity of various types of human tumors including breast, prostate, bone and colon cancers. | | | Catalog # | E1051-01A | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:16,000 | | Western Blot: 1.0-3.0ug/ml. Detects a band of ~80kD in human placenta and duodenum cell lysates. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in TBS, pH7.3, 0.02% sodium azide, 0.5% BSA. | | Purity | Purified by affinity chromatography. | | Immunogen | Peptide sequence C-QDYEEKTKKAER from the internal region of ezrin (NP_003370.2). | | Specificity | Recognizes human ezrin, otherwise known as villin 2. Based on sequence similarity, is expected to react with canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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