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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -ECSIT, CT (Evolutionarily Conserved Signaling Intermediate in Toll Pathway, Evolutionarily Conserved Signaling Intermediate in Toll Pathways, ECSIT Homolog, ECSIT Protein, Signaling Intermediate in Toll Pathway Evolutionarily Conserved, SITPEC, SITPEC Pro

Anti -ECSIT, CT (Evolutionarily Conserved Signaling Intermediate in Toll Pathway,
Evolutionarily Conserved Signaling Intermediate in Toll Pathways, ECSIT Homolog, ECSIT
Protein, Signaling Intermediate in Toll Pathway Evolutionarily Conserved, SITPEC, SITPEC
Pro

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified E B IH
Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)- 6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
Catalog #E2000-25H
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Ion Exchange chromatography.
ImmunogenSynthetic peptide corresponding to 14aa near the C-terminus of human ECSIT.
SpecificityRecognizes human ECSIT. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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