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Anti -EDG 1 (Endothelial Cell Differentiation Gene 1)
Anti -EDG 1 (Endothelial Cell Differentiation Gene 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Endothelial Cell Differentiation Gene-1, or EDG-1, encodes a 44kD protein belonging to a family of G-Protein Coupled Receptors (GPCR’s), which bind lysophospholipids. To date, 8 members of the EDG receptor family have been identified. These receptors are suggested to have a role in modulation of growth-related effects including cell proliferation and differentiation as well as protective, anti-apoptotic effects. EDG receptor expression is developmentally regulated and the expression of the 8 members of this family of proteins appears to be tissue specific. EDG receptors couple to G-proteins to signal through Ras and MAPK pathways and other protein tyrosine kinase pathways. EDG-1 is also known as S1P1. The ligand for EDG-1 is sphingosine-1-phosphate. EDG-1 is expressed predominantly by endothelial cells, as wells as epithelial, neuronal, and cardiovascular cells, but is completely absent from T-lymphocytes. EDG-1 appears to be important in PDGF-mediated chemotaxis with embryonic fibroblasts. EDG-1 plays a major role in neuronal function, development and pathology. | | | Catalog # | E2208 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 5-10ug/mL | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.08% sodium azide. | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide corresponding to the C terminal region of the human EDG-1 protein. | | Specificity | Recognizes human EDG-1 protein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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