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You are here:Home » Antibodies » Abs to G Proteins » Anti -EDG 1 (Endothelial Cell Differentiation Gene 1)

Anti -EDG 1 (Endothelial Cell Differentiation Gene 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Endothelial Cell Differentiation Gene-1, or EDG-1, encodes a 44kD protein belonging to a family of G-Protein Coupled Receptors (GPCR’s), which bind lysophospholipids. To date, 8 members of the EDG receptor family have been identified. These receptors are suggested to have a role in modulation of growth-related effects including cell proliferation and differentiation as well as protective, anti-apoptotic effects. EDG receptor expression is developmentally regulated and the expression of the 8 members of this family of proteins appears to be tissue specific. EDG receptors couple to G-proteins to signal through Ras and MAPK pathways and other protein tyrosine kinase pathways. EDG-1 is also known as S1P1. The ligand for EDG-1 is sphingosine-1-phosphate. EDG-1 is expressed predominantly by endothelial cells, as wells as epithelial, neuronal, and cardiovascular cells, but is completely absent from T-lymphocytes. EDG-1 appears to be important in PDGF-mediated chemotaxis with embryonic fibroblasts. EDG-1 plays a major role in neuronal function, development and pathology.
Catalog #E2208
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 5-10ug/mL
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.08% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to the C terminal region of the human EDG-1 protein.
SpecificityRecognizes human EDG-1 protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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