Anti -EDG1 (Endothelial Cell Differentiation Gene 1, ECGF1, EDG 1, EDG-1, Endothelial
Differentiation G-Protein Coupled Receptor 1, CD363, CHEDG1, D1S3362, FLJ58121,
Sphingosine 1-phosphate Receptor 1, S1P Receptor 1, S1P1, S1PR1, Sphingosine 1-phosphate
Recept
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| Edg-1 is a heterotrimeric orphan receptor for lysosphingolipid sphingosine 1-phosphate (S1P) and belongs to the G-protein coupled receptor 1 family with seven putative transmembrane domains. Human Edg-1 is a highly inducible and abundant endothelial cell GPR that helps in the regulation of differentiation of endothelial cells. S1P-induced endothelial cell migration requires the PKB:AKT1 mediated phosphorylation of Edg-1. Activation of Edg-1 induces cell-cell adhesion and it also helps in modulating intracellular Ca2+ homeostasis. It is rapidly induced when endothelial cells are treated with the tumor promoter phorbol 12-myristate 13-acetate (PMA) and super induced in the presence of cycloheximide. Over expression of Edg-1 leads to cell-cell aggregation, enhanced expression of cadherins and formation of well-developed adherens junctions. Edg-1 is widely expressed in many tissues with low expression in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. | | | Catalog # | E2208-03A | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 2-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human lung lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa340-400 of human Edg-1. | | Specificity | Recognizes human SIP1 receptor/Edg-1. Species sequence homology: chimnpanzee, bovine, canine, equine, chicken, mouse, macaque. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Endothelial Differentiation Sphingolipid G Protein Coupled Receptor 1, G Protein Coupled Sphingolipid Receptor |
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Download Specifications for Anti -EDG1 (Endothelial Cell Differentiation Gene 1, ECGF1, EDG 1, EDG-1, Endothelial Differentiation G-Protein Coupled Receptor 1, CD363, CHEDG1, D1S3362, FLJ58121, Sphingosine 1-phosphate Receptor 1, S1P Receptor 1, S1P1, S1PR1, Sphingosine 1-phosphate Recept |
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