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You are here:Home » Antibodies » Antibodies-G Protein Receptors » Anti -EDG 6 (Endothelial Cell Differentiation Gene 6, S1P4, Sphingosine-1-phosphate Receptor 3, S1PR3, G-Protein Coupled Receptor 6)

Anti -EDG 6 (Endothelial Cell Differentiation Gene 6, S1P4, Sphingosine-1-phosphate
Receptor 3, S1PR3, G-Protein Coupled Receptor 6)


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Clone Host Grade Applications
Polyclonal Rabbit Purified B
Endothelial Cell Differentiation Gene-6, or EDG-6, encodes a 45kD protein belonging to a family of G-Protein Coupled Receptors (GPCR’s), which bind lysophospholipids. To date, 8 members of the EDG receptor family have been identified. These receptors are suggested to have a role in modulation of growth-related effects including cell proliferation and differentiation as well as protective, anti-apoptotic effects. EDG receptor expression is developmentally regulated and the expression of the 8 members of this family of proteins appears to be tissue specific. EDG receptors couple to G-proteins to signal through Ras and MAPK pathways and other protein tyrosine kinase pathways. EDG-6 is also known as S1P4. The ligand for EDG-6 is sphingosine-1-phosphate. EDG-6 is expressed by lymphoid and hematopoietic tissues and also by lung tissue.
Catalog #E2208-30
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 5-10ug/ml. It is recommended to use Pierce Femto Signal substrate for Western Blot development due to the low expression levels of EDG receptors.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS containing 0.08% sodium azide, before the addition of glycerol to 40%.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide corresponding to the C terminal region of the human EDG-6 protein.
SpecificityRecognizes human EDG 6.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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