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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -EDG 6 (Endothelial Differentiation G-protein Coupled Receptor 6, EDG6, LPC1, SLP4, Sphingosine 1-phosphate Receptor 4, S1P Receptor 4, S1P4, S1PR4, Sphingosine 1-phosphate Receptor Edg-6, S1P Receptor Edg-6)

Anti -EDG 6 (Endothelial Differentiation G-protein Coupled Receptor 6, EDG6, LPC1, SLP4,
Sphingosine 1-phosphate Receptor 4, S1P Receptor 4, S1P4, S1PR4, Sphingosine 1-phosphate
Receptor Edg-6, S1P Receptor Edg-6)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IF
Edg6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), which are structurally related lysophospholipid mediators. Binding of SPP to Edg6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein also acts as a receptor for a lipid-derived ligand. Edg6 plays an essential role in lymphocyte cell signaling. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human Edg6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker.
Catalog #E2208-30D
ApplicationsSuitable for use in Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunofluorescence (IC): 5ug/ml
Immunohistochemistry: Paraffin sections
Western Blot: 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat and RAW cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a portion of aa1-50 of human Sphingolipid Receptor Edg6/S1P4 (NP_003766)
SpecificityRecognizes human Sphingolipid Receptor Edg6/S1P4.
Species CrossreactivityMouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEndothelial Cell Differentiation Gene 6


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