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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1, Eukaryotic Translation Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A)

Anti -EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1, Eukaryotic Translation
Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
EIF2 is a translation initiation factor that catalyzes the first regulated step of protein synthesis, promoting the binding of the initiator tRNA to 40s ribosomal subunits. eIF2 is composed of 3 non identical subunits, alpha, beta and gamma. Binding occurs as a ternary complex of methionyl-tRNA, eIF2 and GTP. The rate of complex formation is modulated by the phosphorylation state of eIF2alpha. Phosphorylation of eIF2alpha has been shown to occur in response to heat shock and hypoxic stress. Once eIF2alpha is phosphorylated, the initiation of protein synthesis is inhibited. Expression of eIF-2alpha has been shown to increase in melanoma and colon carcinoma.
Catalog #E2237-01D
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone NoAT5E10
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to human EIF2S1.
SpecificityRecognizes human EIF2S1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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