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You are here:Home » Molecular Biology » MB-Translation Initiation Factors » EIF2S1, aa1-315, Recombinant, Human (Eukaryotic Translation Initiation Factor 2 Subunit 1, Eukaryotic Translation Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2A)

EIF2S1, aa1-315, Recombinant, Human (Eukaryotic Translation Initiation Factor 2 Subunit 1,
Eukaryotic Translation Initiation Factor 2 Subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha,
EIF2A)

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Specifications

EIF2S1, also known as eIF2a, is the alpha subunit of the translation initiation factor eIF2 complex which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. The phosphorylation state of eIF2S1 controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2S1 is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
Catalog #E2237-02
SourceRecombinant corresponding to aa1-315 of human EIF2S1 6x his tagged, expressed in E.coli.
AA SequencesMGSSHHHHHH SSGLVPRGSH MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT TLERTEGLSV
LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV DGDDDAEEME AKAED
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight38.2kD
SourceE.coli
Purity~85% (SDS-PAGE).
Concentration~0.5mg/ml
FormSupplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 0.1M sodium chloride.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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