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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Emerin

Anti -Emerin

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E IH
Emerin is a serine rich protein ubiquitously expressed with highest concentration in skeletal and cardiac muscles. It is localized in the nuclear membrane and is coded by STA gene at Xq28 locus. Emerin deficiency is the main causal feature of Emery-Dreifuss muscular dystrophy (EDMD), which is a X-linked disorder leading to weakening of muscles and cardiomyopathy presented as heart block.
Catalog #E2257
Epitope Near N-terminus
ApplicationsImmunohistology (Formalin/paraffin): (Ab at 1:10 for 60 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Positive Control Tonsil
Cellular Localization Perinuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5G95
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid with 0.09% sodium azide.
PurityCulture supernatant
ImmunogenRecombinant protein corresponding to 222 amino acid fragment near N-terminus of human emerin protein.
SpecificityRecognizes Emerin. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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