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Specifications

Clone Host Grade Applications Monoclonal Mouse Supernatant E IH

Emerin is a serine rich protein ubiquitously expressed with highest concentration in skeletal and cardiac muscles. It is localized in the nuclear membrane and is coded by STA gene at Xq28 locus. Emerin deficiency is the main causal feature of Emery-Dreifuss muscular dystrophy (EDMD), which is a X-linked disorder leading to weakening of muscles and cardiomyopathy presented as heart block.
Catalog #	E2257
Epitope	Near N-terminus
Applications	Immunohistology (Formalin/paraffin): (Ab at 1:10 for 60 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Positive Control	Tonsil
Cellular Localization	Perinuclear
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	5G95
Host	Mouse
Source	Human
Concentration	Not determined
Form	Supplied as a liquid with 0.09% sodium azide.
Purity	Culture supernatant
Immunogen	Recombinant protein corresponding to 222 amino acid fragment near N-terminus of human emerin protein.
Specificity	Recognizes Emerin. Species Crossreactivity: Human.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.