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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Emerin (Leu12)

Anti -Emerin (Leu12)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit B IP
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Emerin is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and Aand B-type lamins, which are important in nuclear functions (2-5). Emerin may regulate gene expression through binding to other transcriptional regulators (6,7). Emerin binds to -catenin and inhibits its nuclear accumulation (8). Emerin is known to interact with nuclear lamins, barrier-to-autointegration factor (BAF), nesprin-1alpha , and a transcription repressor. Recent studies demonstrated that Emerin is required for HIV-1 infectivity (9). It is speculated that patients suffering from Emery-Dreifuss muscular dystrophy may have immunity to or show an irregular infection pattern to HIV-1. Mutations in Emerin are a major cause of X-linked recessive Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).
Catalog #E2257-01B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityFor long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
FormSupplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 g/ml BSA and 50% glycerol.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic peptide (KLH-coupled) corresponding to residues surrounding Leu12 of human Emerin.
SpecificityDetects endogenous levels of total Emerin protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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