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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E IH

Endomorphins are recently discovered endogenous opioid peptides composed of four amino acids: Endomorphin-1 (EM-1) is Tyr-Pro-Trp-Phe-NH2, and Endomorphin-2 (EM-2) is Tyr-Pro-Phe-Phe-NH2. These peptides have a very high affinity and specificity for mu-opioid receptors as it has been reported in many pharmacological studies. EM-1 is distributed in many brain regions, whereas EM-2 is prevalent in brainstem and spinal cord. EM-1 and EM-2 exert their antinociceptive activity by interacting with mu-opioid receptors. EM-1 anf EM-2 bind with mu-opioid receptor with high affinity and selectivity in comparison with binding to opioid delta and kappa receptors. EM-1 and EM-2 tetrapeptides activate G-proteins and inhibit adenylyl cyclase activity when bind to mu-opioid receptors.
Catalog #	E2291-02
Applications	Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilutions	Immunohistochemistry (Immunofluorescence): 15mg/ml
	Immunohistochemistry (Avidin-Biotin): 5mg/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, 0.1% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Concentration	~1mg/ml
Form	Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O, 0.1% sodium azide..
Purity	Purified by affinity chromatography.
Immunogen	Synthetic peptide corresponding to Endomorphin 1, Tyr-Pro-Trp-Phe-NH2 (BSA)
Specificity	Recognizes Endomorphin 1. Displays 5% crossreactivity with Endomorphin 2, <0.03% with Met5-Enkephalin and <0.01% with Leu5-Enkephalin and beta-Endorphin. Species Crossreactivity: rat, mouse, human, porcine and monkey.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.